Pyridine Precursors of Mouse Liver
نویسنده
چکیده
We have previously reported that a single injection of nicotinamide into mice leads to over a lo-fold increase in liver diphosphopyridine nucleotide (DPN) (1). The maximal increase in DPN concentration occurred from 8 to 12 hours after administration of the nicotinamide; this increase is followed by a pronounced decrease, and after 24 hours the DPN level is essentially the same as that of the uninjected controls.’ The fact that the mouse will readily convert nicotinamide into DPN led us to investigate other pyridine compounds as possible coenzyme precursors. The effectiveness of some pyridine derivatives as DPN precursors and as nicotinamide antagonists will be presented in this communication. Materials and Methods
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